Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner
Abstract
Extrachromosomal DNA can integrate into the genome with no sequence specificity producing an insertional mutation. This process, which is referred to as random integration (RI), requires a double stranded break (DSB) in the genome. Inducing DSBs by various means, including ionizing radiation, increases the frequency of integration. Here we report that non-lethal physiologically relevant doses of ionizing radiation (10–100 mGy), within the range...
Paper Details
Title
Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner
Published Date
Jan 16, 2020
Journal
Volume
16
Issue
1
Pages
e1008550 - e1008550
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