Sea Cucumber Stichopus japonicus Hydrolysate Alleviates Late-onset-hypogonadism in Aged SD Rats

Objective: We assessed the andropause (=male climacteric syndrome)-relief effects of the sea cucumber (Stichopus japonicus) samples in an in vivo animal model using aged male SD rats (24 weeks old). Methods: During the experimental period, G1 (control group) received saline, and G2, G3, and G4 were administered 250 mg/kg of sea cucumber hot water extract, sea cucumber fermented by Cordycepe mili-taris, and hydrolysate of sea cucumber, daily by...