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Effect of vitamin D3 supplementation on vascular and metabolic health of vitamin D-deficient overweight and obese children: a randomized clinical trial.

Published on Jan 17, 2020in The American Journal of Clinical Nutrition6.568
· DOI :10.1093/ajcn/nqz340
Kumaravel Rajakumar14
Estimated H-index: 14
(University of Pittsburgh),
Charity G. Moore46
Estimated H-index: 46
(University of Pittsburgh)
+ 6 AuthorsSteven E. Reis52
Estimated H-index: 52
(University of Pittsburgh)
Abstract
  • References (61)
  • Citations (2)
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References61
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#1Joon Young Kim (University of Pittsburgh)H-Index: 9
#2Fida Bacha (BCM: Baylor College of Medicine)H-Index: 31
Last. Silva A. Arslanian (University of Pittsburgh)H-Index: 64
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OBJECTIVE Adipose tissue insulin resistance is one of the pathophysiological components of type 2 diabetes. Herein we investigated: 1) adipose insulin resistance index (Adipose-IR) (calculated as fasting insulin × free fatty acids [FFAs]) in youth across the spectrum of adiposity from normal weight to obese and the spectrum from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) to type 2 diabetes, 2) the relationship of Adipose-IR with physical and metabolic characteristics, and...
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#1JoAnn E. Manson (Harvard University)H-Index: 235
#2Nancy R. Cook (Harvard University)H-Index: 107
Last. Julie E. Buring (Harvard University)H-Index: 155
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Abstract Background It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. Methods We conducted a nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (cholecalciferol) at a dose of 2000 IU per day and marine n−3 (also called omega-3) fatty acids at a dose of 1 g per day for the prevention of cancer and cardiovascular disease among men 50 years of age or...
137 CitationsSource
#1Ian D. Ferguson (University of Pittsburgh)H-Index: 1
#2Patricia Griffin (University of Pittsburgh)H-Index: 5
Last. Abbe N. Vallejo (University of Pittsburgh)H-Index: 22
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T cells are considered autoimmune effectors in Juvenile Idiopathic Arthritis (JIA), but the antigenic cause of arthritis remains elusive. Since T cells comprise a significant proportion of joint-infiltrating cells, we examined whether the environment in the joint could be shaped through the inflammatory activation by T cells that is independent of conventional TCR signaling. We focused on the analysis of synovial fluid (SF) collected from children with oligoarticular and rheumatoid factor-negati...
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#1Tatsuya Maruhashi (Hiroshima University)H-Index: 19
#2Junko Soga (Hiroshima University)H-Index: 20
Last. Yukihito Higashi (Hiroshima University)H-Index: 54
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Background The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. Methods and Results We measured flow‐mediated vasodilat...
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#1Sayyed Saeed Khayyatzadeh (MUMS: Mashhad University of Medical Sciences)H-Index: 1
Last. Majid Ghayour-Mobarhan (MUMS: Mashhad University of Medical Sciences)H-Index: 32
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Background: Vitamin D deficiency is a prevalent and important global health problem. Because of its role in growth and development, vitamin D status is likely to be particularly important in adolescent girls. Here we explored the effects of high-dose vitamin D supplementation on cardiometabolic risk factors. Methods: We have examined the effects of vitamin D supplementation on cardio-metabolic risk factors in 988 healthy adolescent girls in Iran. Fasting blood samples and anthropometric measurem...
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Abstract Humans are able to synthesize vitamin D 3 in their skin when exposed to UV-B, but seasonal variations, textile coverage and predominant indoor activities often make supplementation with the compound necessary. There is some dispute on the desired vitamin D status, measured via the serum concentration of the most stable vitamin D 3 metabolite, 25-hydroxyvitamin D 3 , and the respective recommended daily supplementation. A possible answer may be provided by the concept of the personal vit...
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#1Seyed-Amir Tabatabaeizadeh (MUMS: Mashhad University of Medical Sciences)H-Index: 3
#2Amir AvanH-Index: 24
Last. Majid Ghayour-MobarhanH-Index: 32
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The prevalence of Vitamin D deficiency is increasing worldwide, which has be shown to be associated with increased risk of cardiovascular disease (CVD), autoimmune disease, and metabolic syndrome. These conditions are also associated with a heightened state of inflammation. The aim of the current study was to evaluate the effect of vitamin D supplementation on serum C-Reactive Protein (CRP) level and Neutrophil-to-lymphocyte ratio (NLR) distribution in a large cohort of adolescent girls. A total...
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#1John D. Sluyter (University of Auckland)H-Index: 8
#2Carlos A. Camargo (Harvard University)H-Index: 106
Last. Robert Scragg (University of Auckland)H-Index: 51
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BackgroundThe effects of monthly, high‐dose, long‐term (≥1‐year) vitamin D supplementation on central blood pressure (BP) parameters are unknown. Methods and ResultsA total of 517 adults (58% male,...
21 CitationsSource
#1C.E. Shaaban (Graduate School USA)H-Index: 1
Last. C. Rosano (Graduate School USA)H-Index: 1
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BACKGROUND AND PURPOSE: Traditional neuroimaging markers of small-vessel disease focus on late-stage changes. We aimed to adapt a method of venular assessment at 7T for use in older adults. We hypothesized that poorer venular morphologic characteristics would be related to other small-vessel disease neuroimaging markers and a higher prevalence of small-vessel disease–Alzheimer disease risk factors. MATERIALS AND METHODS: Venules were identified in periventricular ROIs on SWI and defined as tortu...
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#1Arshad T. KhalidH-Index: 1
#2Charity G. MooreH-Index: 46
Last. Kumaravel RajakumarH-Index: 14
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