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Atmospheric Solids Analysis Probe Coupled to a Portable Mass Spectrometer for Rapid Identification of Bulk Drug Seizures

Published on Feb 5, 2020in Journal of the American Society for Mass Spectrometry3.202
· DOI :10.1021/jasms.9b00020
Bryan J. McCullough (Queen's University), Bryan J. McCullough11
Estimated H-index: 11
+ 6 AuthorsChris Hopley (Queen's University)
Abstract
The emergence of ambient ionization techniques and their combination with smaller, cheaper mass spectrometers is beginning to make real the possibility of mass spectrometry measurements being made routinely outside of traditional laboratory settings. Here, we describe the development of an atmospheric solids analysis probe (ASAP) source for a commercially available miniaturized, single-quadrupole mass spectrometer and subsequent modification of the instrument to allow it to run as a deployable system; we further go on to describe the application of this instrument to the identification of the contents of drug seizures. For the drug seizure analysis, a small quantity of the material (powder, tablet, resin, etc.) was dissolved in ethanol and shaken to extract the analytes, the resulting solutions were then sampled by dipping a sealed glass capillary into the solution prior to analysis by ASAP–MS. Identification of the contents of the seizures was carried out using a NIST searching approach utilizing a bespo...
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