The MORN domain of Junctophilin2 regulates functional interactions with small‐conductance Ca ²⁺ ‐activated potassium channel subtype2 (SK2)

Small‐conductance Ca 2+ ‐activated K + channel subtype2 (SK2) are stable macromolecular complexes that regulate myocardial excitability and Ca 2+ homeostasis. Junctophilin‐2 (JP2) is a membrane‐binding protein, which provides functional crosstalk by physically linking with the cell‐surface and intracellular ion channels. We previously demonstrated that the MORN domain of JP2 interacts with SK2 channels. However, the roles of the JP2 MORN domain...