Extreme Downregulation of Chromosome Y and Cancer Risk in Men

Background Understanding the biological differences between sexes in cancer is essential for personalized treatment and prevention. We hypothesized that the extreme downregulation of chromosome Y gene expression (EDY) is a signature of cancer risk in men and the functional mediator of the reported association between the mosaic loss of chromosome Y (LOY) and cancer. Methods We advanced a method to measure EDY from transcriptomic data. We studied...