Match!

The NMN Module Conducts Nodule Number Orchestra

Published on Feb 21, 2020in iScience
· DOI :10.1016/j.isci.2020.100825
Zhijuan Wang (HAU: Huazhong Agricultural University), Lixiang Wang (Henan University)+ 1 AuthorsXia Li7
Estimated H-index: 7
(HAU: Huazhong Agricultural University)
Abstract
Abstract Legumes control nodule number through nodulation and autoregulation of nodulation (AON) pathways. Nodule Inception (NIN) is essential for rhizobial infection and nodule organogenesis in legumes. The GmNINa-miR172c-NNC1 (NMN) module, which consists of two positive regulators, GmNINa and miR172c, and a suppressor, NNC1, integrates both pathways. GmNINa activates miR172c to downregulate NNC1, leading to nodulation, while NNC1 inhibits miR172c expression, forming a negative feedback loop. GmNINa and NNC1 interact with each other and antagonistically fine-tune GmRIC1/RIC2 expression, turning AON on and off. Conversely, activation of AON inhibits GmNINa and miR172c expression, thereby reducing their inhibitory effects on NNC1 to attenuate both nodulation signalling and AON. The NMN module functions not only as an “accelerator” of the nodulation signal to promote nodulation but also as a “brake” on the signal by activating AON to orchestrate nodule number.
  • References (47)
  • Citations (0)
📖 Papers frequently viewed together
143 Citations
2007
3 Authors (Liqi Han, ..., Jim Hanan)
4 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References47
Newest
#1Takashi Soyano (National Institute for Basic Biology, Japan)H-Index: 20
#2Yoshikazu Shimoda (National Agriculture and Food Research Organization)H-Index: 19
Last. Makoto Hayashi (National Agriculture and Food Research Organization)H-Index: 49
view all 4 authors...
Legumes develop root nodules in symbiosis with nitrogen-fixing rhizobial bacteria. Rhizobia evoke cell division of differentiated cortical cells into root nodule primordia for accommodating bacterial symbionts. In this study, we show that NODULE INCEPTION (NIN), a transcription factor in Lotus japonicus that is essential for initiating cortical cell divisions during nodulation, regulates the gene ASYMMETRIC LEAVES 2-LIKE18/LATERAL ORGAN BOUNDARIES DOMAIN16a (ASL18/LBD16a). Orthologs of ASL18/LBD...
4 CitationsSource
#1Katharina Schiessl (University of Cambridge)H-Index: 1
#2Jodi L.S. Lilley (Norwich Research Park)H-Index: 1
Last. Giles E. D. Oldroyd (University of Cambridge)H-Index: 61
view all 15 authors...
Summary To overcome nitrogen deficiencies in the soil, legumes enter symbioses with rhizobial bacteria that convert atmospheric nitrogen into ammonium. Rhizobia are accommodated as endosymbionts within lateral root organs called nodules that initiate from the inner layers of Medicago truncatula roots in response to rhizobial perception. In contrast, lateral roots emerge from predefined founder cells as an adaptive response to environmental stimuli, including water and nutrient availability. CYTO...
5 CitationsSource
#1Lixiang Wang (HAU: Huazhong Agricultural University)H-Index: 1
#2Zhengxi Sun (HAU: Huazhong Agricultural University)H-Index: 1
Last. Xia Li (HAU: Huazhong Agricultural University)H-Index: 7
view all 8 authors...
Abstract Symbiotic root nodules are root lateral organs of plants in which nitrogen-fixing bacteria (rhizobia) convert atmospheric nitrogen to ammonia. The formation and number of nodules in legumes are precisely controlled by a rhizobia-induced signal cascade and host-controlled autoregulation of nodulation (AON). However, how these pathways are integrated and their underlying mechanisms are unclear. Here, we report that the microRNA172c (miR172c) activates soybean ( Glycine max ) Rhizobia-Indu...
1 CitationsSource
#1Takuya Suzaki (University of Tsukuba)H-Index: 21
#2Hanna Nishida (National Agriculture and Food Research Organization)H-Index: 1
2 CitationsSource
#1Chengwu Liu (JIC: John Innes Centre)H-Index: 12
#2Andrew Breakspear (JIC: John Innes Centre)H-Index: 5
Last. Jeremy D. Murray (CAS: Chinese Academy of Sciences)H-Index: 3
view all 17 authors...
The symbiotic infection of root cells by nitrogen-fixing rhizobia during nodulation requires the transcription factor Nodule Inception (NIN). Our root hair transcriptomic study extends NIN’s regulon to include Rhizobium Polar Growth and genes involved in cell wall modification, gibberellin biosynthesis, and a comprehensive group of nutrient (N, P, and S) uptake and assimilation genes, suggesting that NIN’s recruitment to nodulation was based on its role as a growth module, a role shared with oth...
5 CitationsSource
#1Daniela Tsikou (AU: Aarhus University)H-Index: 1
#2Zhe Yan (AU: Aarhus University)H-Index: 9
Last. Katharina Markmann (University of Tübingen)H-Index: 11
view all 10 authors...
Nitrogen-fixing root nodules on legumes result from two developmental processes, bacterial infection and nodule organogenesis. To balance symbiosis and plant growth, legume hosts restrict nodule numbers through an inducible autoregulatory process. Here, we present a mechanism where repression of a negative regulator ensures symbiotic susceptibility of uninfected roots of the host Lotus japonicus . We show that microRNA miR2111 undergoes shoot-to-root translocation to control rhizobial infection ...
27 CitationsSource
#1Jie-shun Lin (CAS: Chinese Academy of Sciences)H-Index: 1
#2Xiaolin Li (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Fang Xie (CAS: Chinese Academy of Sciences)H-Index: 6
view all 6 authors...
Legume plants can assimilate inorganic nitrogen and have access to fixed nitrogen through symbiotic interaction with diazotrophic bacteria called rhizobia. Symbiotic nitrogen fixation is an energy-consuming process and is strongly inhibited when sufficient levels of fixed nitrogen are available, but the molecular mechanisms governing this regulation are largely unknown. The transcription factor nodule inception (NIN) is strictly required for nodulation and belongs to a family of NIN-like protein...
6 CitationsSource
#1Maximilian Griesmann (LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2Yue ChangH-Index: 3
Last. Shifeng ChengH-Index: 18
view all 42 authors...
The root nodule symbiosis of plants with nitrogen-fixing bacteria impacts global nitrogen cycles and food production but is restricted to a subset of genera within a single clade of flowering plants. To explore the genetic basis for this scattered occurrence, we sequenced the genomes of ten plant species covering the diversity of nodule morphotypes, bacterial symbionts and infection strategies. In a genome-wide comparative analysis of a total of 37 plant species, we discovered signatures of mult...
40 CitationsSource
#1Robin van Velzen (WUR: Wageningen University and Research Centre)H-Index: 8
#2Rens Holmer (WUR: Wageningen University and Research Centre)H-Index: 4
Last. Rene Geurts (WUR: Wageningen University and Research Centre)H-Index: 23
view all 31 authors...
Nodules harboring nitrogen-fixing rhizobia are a well-known trait of legumes, but nodules also occur in other plant lineages, with rhizobia or the actinomycete Frankia as microsymbiont. It is generally assumed that nodulation evolved independently multiple times. However, molecular-genetic support for this hypothesis is lacking, as the genetic changes underlying nodule evolution remain elusive. We conducted genetic and comparative genomics studies by using Parasponia species (Cannabaceae), the o...
30 CitationsSource
#1Hanna Nishida (National Institute for Basic Biology, Japan)H-Index: 4
#2Sachiko Tanaka (National Institute for Basic Biology, Japan)H-Index: 4
Last. Takuya Suzaki (University of Tsukuba)H-Index: 21
view all 11 authors...
Legumes and rhizobia establish symbiosis in root nodules. To balance the gains and costs associated with the symbiosis, plants have developed two strategies for adapting to nitrogen availability in the soil: plants can regulate nodule number and/or stop the development or function of nodules. Although the former is accounted for by autoregulation of nodulation, a form of systemic long-range signaling, the latter strategy remains largely enigmatic. Here, we show that the Lotus japonicus NITRATE U...
22 CitationsSource
Cited By0
Newest