Preparation of novel RGD-conjugated thermosensitive mPEG-PCL composite hydrogels and in vitro investigation of their impacts on adhesion-dependent cellular behavior

The arginine–glycine–aspartic acid (RGD) motif plays a critical role in cell-extracellular matrix (ECM) interactions through focal adhesion, which may orchestrate various aspects of cellular behaviors for development and maintenance of tissues. Here, we prepared novel thermosensitive hydrogel systems comprising methoxy polyethylene glycol-b-polycaprolactone (MP) and RGD-conjugated MP (MP-RGD) with various RGD contents (MP/MP-RGD) based on our...