Exogenous 8‐hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1‐NADPH oxidase signaling

Background and Aim Exogenous 8‐hydroxydeoxyguanosine (8‐OHdG) was suggested as an inhibitor of Rac1 and NADPH oxidase (NOX). The aim of this study was to evaluate the effects of the exogenous 8‐OHdG on hepatic fibrogenesis in vitro and in vivo model of liver fibrosis. Methods Adult Sprague–Dawley rats were allocated to sham‐operated rats ( n = 7), rats that underwent bile duct ligation (BDL) (n = 6), and BDL rats treated with 8‐OHdG (60...