PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling

PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation, extracellular matrix remodeling, and mitogens.Here, we applied a systems biology approach to gain deeper insights into the PCSK6 role in normal and diseased vessel wall.Genetic analyses revealed...