Crucial relationship of Neural Wiskott Aldrich syndrome protein(N-WASP) and Lysyl oxidase-like 2(LOXL2) in the promotion of pancreatic cancer metastasis

Introduction: Pancreatic cancer has been widely known to have aggressive malignancy and poor prognosis. N-WASP is part of the WASP family that regulate actin polymerization by activating Arp2/3 complex. FAK(Focal adhesion kinase) promotes N-WASP and epithelial mesenchymal transition(EMT) in cancer metastasis. The overexpression of LOXL2 promotes distant metastasis in pancreatic cancer. However, there is insufficient evidence of the relationship...