Homozygous mutation of foxh1 arrests oogenesis causing infertility in female Nile tilapia†

Volume: 102, Issue: 3, Pages: 758 - 769
Published: Dec 14, 2019
Abstract
Foxh1, a member of fox gene family, was first characterized as a transcriptional partner in the formation of the Smad protein complex. Recent studies have shown foxh1 is highly expressed in the cytoplasm of oocytes in both tilapia and mouse. However, its function in oogenesis remains unexplored. In the present study, foxh1−/− tilapia was created by CRISPR/Cas9. At 180 dah (days after hatching), the foxh1−/− XX fish showed oogenesis arrest and a...
Paper Details
Title
Homozygous mutation of foxh1 arrests oogenesis causing infertility in female Nile tilapia†
Published Date
Dec 14, 2019
Volume
102
Issue
3
Pages
758 - 769
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