Collismycin C reduces HMGB1-mediated septic responses and improves survival rate in septic mice
Volume: 23, Issue: 1, Pages: 55 - 72
Published: Dec 31, 2019
Abstract
We examined the effects of a 2,2′-bipyridine containing natural product, collismycin C on high mobility group box 1 (HMGB1, septic mediator)-mediated septic responses and survival rate in a mouse sepsis model. Collismycin C inhibited the HMGB1 release and downregulated HMGB1-mediated inflammatory responses in human endothelial cells. Collismycin C also inhibited HMGB1-induced hyperpermeability and leukocyte migration in mice. In addition,...
Paper Details
Title
Collismycin C reduces HMGB1-mediated septic responses and improves survival rate in septic mice
Published Date
Dec 31, 2019
Volume
23
Issue
1
Pages
55 - 72
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