Swiprosin-1/ EFhd2: from Immune Regulator to Personality and Brain Disorders

Swiprosin-1/ EF-hand domain 2 (EFhd2) is a Ca2+ sensor protein that plays an important role in the immune system. Its abundant expression in the brain, however, suggested also a role in neuronal circuits and behavior.Here we review recent discoveries on the structure and molecular function, its role in immunity and its function in the brain regarding behavioral control and pathologies.While EFhd2 did not emerge as a vital protein for brain...