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Swiprosin-1/ EFhd2: from Immune Regulator to Personality and Brain Disorders.

Published on Jan 1, 2019in Neurosignals
· DOI :10.33594/000000179
Georgios Kogias1
Estimated H-index: 1
,
Georgios Kogias1
Estimated H-index: 1
+ 2 AuthorsChristian P. Müller82
Estimated H-index: 82
Abstract
BACKGROUND/AIMS: Swiprosin-1/ EF-hand domain 2 (EFhd2) is a Ca2+ sensor protein that plays an important role in the immune system. Its abundant expression in the brain, however, suggested also a role in neuronal circuits and behavior. METHODS: Here we review recent discoveries on the structure and molecular function, its role in immunity and its function in the brain regarding behavioral control and pathologies. RESULTS: While EFhd2 did not emerge as a vital protein for brain development, changes in its expression may nevertheless shape the adult behavioral repertoire significantly and contribute to adult personality traits. A defective function of EFhd2 may also render individuals more prone to the development of psychiatric disorders. Most prominently, EFhd2 proved to be a resilience factor protecting from fast establishment of drug addiction. Moreover, EFhd2 is critical for adult neurogenesis and as a modulator of monoaminergic systems. CONCLUSION: Dysregulated activity of EFhd2 is increasingly considered as a contributing factor for the development of numerous neurodegenerative disorders. Whether EFhd2 can be used as biomarker or in therapeutic approaches has to be addressed in future research.
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#2Tommy Pattij (VUmc: VU University Medical Center)H-Index: 42
Last. Christian P. Müller (FAU: University of Erlangen-Nuremberg)H-Index: 82
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