Optimal Impulsive Control With Application to Antiangiogenic Tumor Therapy

An optimal control algorithm is proposed for impulsive differential systems, i.e., systems evolving according to ordinary differential equations between any two control actions, occurring impulsively at discrete-time instants. Measurements are as well acquired at discrete-time instants. A model-based control law is conceived for medical and healthcare frameworks and, indeed, is applied to synthesize a feedback antiangiogenic tumor therapy. To...