Mechanisms of Regulation of the Targeted Grown of Nerves and Vessels by Components of the Fibrinolytic System and GPI-Anchored Navigation Receptors

The targeted growth of nerves and vessels is controlled by navigation receptors, some of which are proteins with glycosylphosphatidylinositide “anchors.” Using T-cadherin and the urokinase receptor as examples, this review addresses the main molecular mechanisms of this process. T-cadherin functions as a navigation molecule negatively regulating the growth of axons and blood vessels. This substance is involved in regulating physiological and...