Simultaneous germline and somatic sequencing in ovarian carcinoma: mutation rate and impact on clinical decision-making

Volume: 156, Issue: 3, Pages: 517 - 522
Published: Mar 1, 2020
Abstract
Objective Germline and somatic BRCA1 and BRCA2 (BRCA) mutations predict treatment response in patients with epithelial ovarian, peritoneal or fallopian tube cancer (OC), yet only germline testing is routinely pursued or reimbursed at diagnosis. We report our experience with clinical testing of paired tumor and germline DNA for OC mutations. Methods Simultaneous sequencing using the BROCA assay of DNA from paired blood and neoplastic tissue...
Paper Details
Title
Simultaneous germline and somatic sequencing in ovarian carcinoma: mutation rate and impact on clinical decision-making
Published Date
Mar 1, 2020
Volume
156
Issue
3
Pages
517 - 522
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