β‐Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents

Background and Purpose β‐Caryophyllene (BCP) is a plant‐derived terpenoid used as a food additive for many decades. Recent studies indicate that BCP is a cannabinoid CB 2 receptor agonist with medical benefits for a number of human diseases. However, little is known about its therapeutic potential for drug abuse and addiction. Experiment Approach We used pharmacological, transgenic, and optogenetic approaches to systematically evaluate the...