Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway

<b><i>Introduction:</i></b> Vascular calcification (VC) is a complex, regulated process involved in many disease entities. So far, there are no treatments to reverse it. Exploring novel strategies to prevent VC is important and necessary for VC-related disease intervention. <b><i>Objective:</i></b> In this study, we evaluated whether MOTS-c, a novel mitochondria-related 16-aa peptide, can reduce...