Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort
Abstract
BACKGROUND. Mitochondrial dysfunction, a proposed mechanism of chronic obstructive pulmonary disease (COPD) pathogenesis, is associated with the leakage of mitochondrial DNA (mtDNA), which may be detected extracellularly in various bodily fluids. Despite evidence for the increased prevalence of chronic kidney disease in COPD subjects and for mitochondrial dysfunction in the kidneys of murine COPD models, whether urine mtDNA (u-mtDNA) associates...
Paper Details
Title
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort
Published Date
Feb 13, 2020
Journal
Volume
5
Issue
3
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