Effect of chemical composition and sulfated modification of alginate in the development of delivery systems based on electrostatic interactions for small molecule drugs

Volume: 263, Pages: 127235 - 127235
Published: Mar 1, 2020
Abstract
The ionic complexation of different chemical compositions of alginate and its sulfated derivative with tetracycline hydrochloride (TCH), as a cationic drug model, was investigated. The complexes of TCH with mannuronate-enriched alginate entrapped the highest amount of the drug. However, the ability of all un-modified alginates for ionic complexation was very weak. Interestingly, the chemical modification of alginate with sulfate groups resulted...
Paper Details
Title
Effect of chemical composition and sulfated modification of alginate in the development of delivery systems based on electrostatic interactions for small molecule drugs
Published Date
Mar 1, 2020
Volume
263
Pages
127235 - 127235
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