Increasing the targeting scope and efficiency of base editing with Proxy‐BE strategy

Base editors (BEs) are widely used in precise gene editing due to their simplicity and versatility. However, their efficiencies are hindered by various obstacles. Considering the chromatin microenvironment as a possible obstacle, here, we demonstrate a further development of the proxy‐clustered regularly interspaced short palindromic repeats strategy, termed Proxy‐BE, to increase gene editing efficiency. Specifically, a nuclease‐dead Cas9...