CEP41‐mediated ciliary tubulin glutamylation drives angiogenesis through AURKA‐dependent deciliation

The endothelial cilium is a microtubule‐based organelle responsible for blood flow‐induced mechanosensation and signal transduction during angiogenesis. The precise function and mechanisms by which ciliary mechanosensation occurs, however, are poorly understood. Although posttranslational modifications ( PTM s) of cytoplasmic tubulin are known to be important in angiogenesis, the specific roles of ciliary tubulin PTM s play remain unclear. Here,...