Original paper
Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1
Abstract
Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and is associated with a poor prognosis due to frequent distant metastasis and lack of effective targeted therapies. Previously, we identified maternal embryonic leucine zipper kinase (MELK) to be highly expressed in TNBCs as compared with ER-positive breast cancers. Here we determined the molecular mechanism by which MELK is overexpressed in TNBCs. Analysis of...
Paper Details
Title
Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1
Published Date
Jan 3, 2020
Journal
Volume
6
Issue
1
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Notes
History