Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors
Abstract
Upon release in response to stress, epinephrine (Epi) may interact with labile iron pool in human plasma with potentially important (patho)physiological consequences. We have shown that Epi and Fe3+ build stable 1:1 high-spin bidentate complex at physiological pH, and that Epi does not undergo degradation in the presence of iron. However, the interactions of Epi with the more soluble Fe2+, and the impact of iron on biological activity of Epi are...
Paper Details
Title
Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors
Published Date
Feb 1, 2020
Volume
148
Pages
123 - 127
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