Editor's cut: DNA cleavage by CRISPR RNA-guided nucleases Cas9 and Cas12a

Volume: 48, Issue: 1, Pages: 207 - 219
Published: Dec 24, 2019
Abstract
Discovered as an adaptive immune system of prokaryotes, CRISPR–Cas provides many promising applications. DNA-cleaving Cas enzymes like Cas9 and Cas12a, are of great interest for genome editing. The specificity of these DNA nucleases is determined by RNA guides, providing great targeting adaptability. Besides this general method of programmable DNA cleavage, these nucleases have different biochemical characteristics, that can be exploited for...
Paper Details
Title
Editor's cut: DNA cleavage by CRISPR RNA-guided nucleases Cas9 and Cas12a
Published Date
Dec 24, 2019
Volume
48
Issue
1
Pages
207 - 219
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