Protecting the Aging Genome

DNA damage accumulates with aging.Defects in DNA repair lead to premature aging.Emerging drugs that target DNA repair may alleviate age-associated phenotypes. Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA damage, including reducing damaging molecules, repairing DNA damage, and inducing senescence or apoptosis in response to persistent DNA damage....