Original paper
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
Abstract
The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole-genome sequencing and phylogenetic analysis of 388 samples across 18 individuals with EAC showed, in 90% of patients, that multiple subclones from the primary tumor spread very rapidly from the primary site to form multiple metastases, including lymph nodes and distant tissues-a mode of dissemination that we term...
Paper Details
Title
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
Published Date
Jan 1, 2020
Journal
Volume
52
Issue
1
Pages
74 - 83
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Notes
History