Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance

Context Multiple islet autoantibody positivity usually precedes clinical (stage 3) type 1 diabetes (T1D). Objective To test the hypothesis that individuals who develop stage 3 T1D with only a single autoantibody have unique metabolic differences. Design Cross-sectional analysis of participants in the T1D TrialNet study. Setting Autoantibody-positive relatives of individuals with stage 3 T1D. Participants Autoantibody-positive relatives who...