Neuronal‐derived extracellular vesicles are enriched in the brain and serum of HIV‐1 transgenic rats

Despite the efficacy of combination antiretroviral therapy (ART) in controlling human immunodeficiency virus (HIV‐1) replication, cytotoxic viral proteins such as HIV‐1 transactivator of transcription (Tat) persist in tissues such as the brain. Although HIV‐1 does not infect neuronal cells, it is susceptible to viral Tat protein‐mediated toxicity, leading to neuroinflammation that underlies HIV‐associated neurocognitive disorders (HAND). Given...