Measurement of Skeletal Muscle Fiber Contractility with High-Speed Traction Microscopy

Volume: 118, Issue: 3, Pages: 657 - 666
Published: Feb 1, 2020
Abstract
We describe a technique for simultaneous quantification of the contractile forces and cytosolic calcium dynamics of muscle fibers embedded in three-dimensional biopolymer gels under auxotonic loading conditions. We derive a scaling law for linear elastic matrices such as basement membrane extract hydrogels (Matrigel) that allows us to measure contractile force from the shape of the relaxed and contracted muscle cell and the Young’s modulus of...
Paper Details
Title
Measurement of Skeletal Muscle Fiber Contractility with High-Speed Traction Microscopy
Published Date
Feb 1, 2020
Volume
118
Issue
3
Pages
657 - 666
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