A Depletion of Stop Codons in lincRNA is Owing to Transfer of Selective Constraint from Coding Sequences.
Abstract
Although the constraints on a gene's sequence are often assumed to reflect the functioning of that gene, here we propose transfer selection, a constraint operating on one class of genes transferred to another, mediated by shared binding factors. We show that such transfer can explain an otherwise paradoxical depletion of stop codons in long intergenic noncoding RNAs (lincRNAs). Serine/arginine-rich proteins direct the splicing machinery by...
Paper Details
Title
A Depletion of Stop Codons in lincRNA is Owing to Transfer of Selective Constraint from Coding Sequences.
Published Date
Apr 1, 2020
Volume
37
Issue
4
Pages
1148 - 1164
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