Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
Abstract
Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimics events occurring in human glaucoma. Senescence‐related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to as the senescence‐associated secretory phenotype (SASP). Emerging evidence suggests that the presence of these proinflammatory and...
Paper Details
Title
Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
Published Date
Dec 22, 2019
Journal
Volume
19
Issue
2
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