Sustained Coevolution in a Stochastic Model of Cancer–Immune Interaction
Abstract
The dynamic interactions between an evolving malignancy and the adaptive immune system generate diverse evolutionary trajectories that ultimately result in tumor clearance or immune escape. Here, we create a simple mathematical model coupling T-cell recognition with an evolving cancer population that may randomly produce evasive subclones, imparting transient protection against the effector T cells. T-cell turnover declines and evasion rates...
Paper Details
Title
Sustained Coevolution in a Stochastic Model of Cancer–Immune Interaction
Published Date
Feb 14, 2020
Journal
Volume
80
Issue
4
Pages
811 - 819
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