Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
Abstract
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on detailed lipoprotein measures and compare those to genetic inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). We used an allele associated with lower CETP expression (rs247617) to mimic CETP inhibition...
Paper Details
Title
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
Published Date
Dec 20, 2019
Journal
Volume
17
Issue
12
Pages
e3000572 - e3000572
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