Ion Binding and Selectivity of the Na+/H+ Antiporter MjNhaP1 from Experiment and Simulation
Abstract
Cells employ membrane-embedded antiporter proteins to control their pH, salt concentration, and volume. The large family of cation/proton antiporters is dominated by Na+/H+ antiporters that exchange sodium ions against protons, but homologous K+/H+ exchangers have recently been characterized. We show experimentally that the electroneutral antiporter NhaP1 of Methanocaldococcus jannaschii (MjNhaP1) is highly selective for Na+ ions. We then...
Paper Details
Title
Ion Binding and Selectivity of the Na+/H+ Antiporter MjNhaP1 from Experiment and Simulation
Published Date
Dec 16, 2019
Volume
124
Issue
2
Pages
336 - 344
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