Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort.
Abstract
An individual’s brainAGE is the difference between chronological age and age predicted from machine-learning models of brain-imaging data. BrainAGE has been proposed as a biomarker of age-related deterioration of the brain. Having an older brainAGE has been linked to Alzheimer’s, dementia, and mortality. However, these findings are largely based on cross-sectional associations which can confuse age differences with cohort differences. To...
Paper Details
Title
Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort.
Published Date
Aug 1, 2021
Journal
Volume
26
Issue
8
Pages
3829 - 3838
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