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Ecology helps bound causal explanations in microbiology

Published on Feb 1, 2020in Biology and Philosophy1.593
· DOI :10.1007/S10539-019-9728-5
Jonathan L. Klassen17
Estimated H-index: 17
(UConn: University of Connecticut)
Abstract
Experimental manipulations are a key means to establish causal relationships in microbiology. However, challenges remain to establish the applicability of such experiments beyond the precise conditions in which they were conducted. Ecological information can help address these challenges by describing the extent to which an experimentally-determined mechanism can explain the natural phenomenon that it is purported to cause.
  • References (13)
  • Citations (1)
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References13
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#1Jonathan L. Klassen (UConn: University of Connecticut)H-Index: 17
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: Even though tremendous progress has been made in the last decades to elucidate the mechanisms of intestinal homeostasis, dysbiosis and disease, we are only at the beginning of understanding the complexity of the gut ecosystem and the underlying interaction networks. We are also only starting to unravel the mechanisms that pathogens have evolved to overcome the barriers imposed by the microbiota and host to exploit the system to their own benefit. Recent work in these domains clearly indicates ...
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