Resolving Spliceosomal Malfunctions Advances RNA-Based Therapeutics
Abstract
Spliceosomes comprise small nuclear (sn)RNAs and proteins. Through genome-wide analyses in large-scale tumor samples, recent studies by Shuai et al., Suzuki et al., and Inoue et al. have identified recurrent spliceosomal mutations that induced genome-wide splicing alterations of cancer-related genes to promote malignancy. These discoveries suggest novel RNA-based therapeutics in anticancer treatment. Spliceosomes comprise small nuclear (sn)RNAs...
Paper Details
Title
Resolving Spliceosomal Malfunctions Advances RNA-Based Therapeutics
Published Date
Feb 1, 2020
Journal
Volume
26
Issue
2
Pages
135 - 137
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