Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) caused by PKD1 mutations is one of the most common hereditary disorders. However, the key pathological processes underlying cyst development and exacerbation in pre-symptomatic stages remain unknown, because rodent models do not recapitulate critical disease phenotypes, including disease onset in heterozygotes. Here, using CRISPR/Cas9, we generate ADPKD models with PKD1 mutations in cynomolgus...
Paper Details
Title
Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
Published Date
Dec 11, 2019
Journal
Volume
10
Issue
1
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