Identification of the Genetic Requirements for Zinc Tolerance and Toxicity inSaccharomyces cerevisiae
Abstract
Zinc is essential for almost all living organisms, since it serves as a crucial cofactor for transcription factors and enzymes. However, it is toxic to cell growth when present in excess. The present work aims to investigate the toxicity mechanisms induced by zinc stress in yeast cells. To this end, 108 yeast single-gene deletion mutants were identified sensitive to 6 mM ZnCl2 through a genome-wide screen. These genes were predominantly related...
Paper Details
Title
Identification of the Genetic Requirements for Zinc Tolerance and Toxicity inSaccharomyces cerevisiae
Published Date
Feb 1, 2020
Journal
Volume
10
Issue
2
Pages
479 - 488
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