Little Change in Functional Brain Networks Following Acute Levodopa in Drug‐Naïve Parkinson's Disease

The objective of this study was to investigate the effects of levodopa on functional brain networks in Parkinson's disease.We acquired resting state functional magnetic resonance imaging in 30 drug-naïve participants with Parkinson's disease and 20 age-matched healthy controls. Each participant was studied following administration of a single oral dose of either levodopa or placebo in a randomized, double-blind, crossover design.The greatest...