Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance
Abstract
Atypical teratoid/rhabdoid tumors (ATRT) are known for their heterogeneity concerning pathophysiology and outcome. However, predictive factors within distinct subgroups still need to be uncovered. Using multiplex immunofluorescent staining and single-cell RNA sequencing we unraveled distinct compositions of the immunological tumor microenvironment (TME) across ATRT subgroups. CD68+ cells predominantly infiltrate ATRT-SHH and ATRT-MYC and are a...
Paper Details
Title
Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance
Published Date
Dec 17, 2019
Journal
Volume
139
Issue
5
Pages
913 - 936
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