Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer
Abstract
In breast cancer, Lysine-specific demethylase-1 (LSD1) and other lysine demethylases (KDMs), such as Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), are co-expressed and co-localize with estrogen receptors (ERs), suggesting the potential use of hybrid (epi)molecules to target histone methylation and therefore regulate/redirect hormone receptor signaling. Here, we report on the...
Paper Details
Title
Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer
Published Date
Dec 16, 2019
Journal
Volume
11
Issue
12
Pages
2027 - 2027
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