Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-α antibody-based therapy
Abstract
The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes (T1D). We determined by GC–MS the extent of asymmetric dimethylation (prADMA) and citrullination (prCit) of l-arginine residues in organ proteins (pr) of normoglycaemic control (ngCo, n = 6), acutely diabetic (acT1D, n = 6), chronically diabetic (chT1D, n = 4), and cured (cuT1D, n = 4) rats after anti-TCR/anti-TNF-α therapy. Pancreatic prCit and prADMA did not differ between the...
Paper Details
Title
Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-α antibody-based therapy
Published Date
Dec 12, 2019
Journal
Volume
52
Issue
1
Pages
103 - 110
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