Original paper
Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology
Abstract
Mixtures risk assessment needs an efficient integration of in vivo, in vitro, and in silico data with epidemiology and human studies data. This involves several approaches, some in current use and others under development. This work extends the Agency for Toxic Substances and Disease Registry physiologically based pharmacokinetic (PBPK) toolkit, available for risk assessors, to include a mixture PBPK model of benzene, toluene, ethylbenzene, and...
Paper Details
Title
Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology
Published Date
Dec 18, 2019
Journal
Volume
174
Issue
1
Pages
38 - 50
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Notes
History