Electrostatic Surface Potential of Macrophages Correlates with Their Functional Phenotype

Macrophages exist in various functional phenotypes, which could be identified by specific surface molecules. Previous studies have shown that modulation of surface charges could alter the phagocytic function of macrophages. In this study, we show that activation of both human peripheral blood monocyte and THP-1-derived macrophages with lipopolysaccharide (LPS) or IL-1β resulted in a significant decrease in the zeta potential compared to freshly...