von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke

Von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ib (GPIb). Over the past decades, it has become clear that many hemostatic factors, including VWF and platelets, are also involved in inflammatory processes, forming intriguing links between hemostasis, thrombosis and inflammation. The so-called...