Development and evaluation of paclitaxel nanoemulsion for cancer therapy
Volume: 25, Issue: 4, Pages: 510 - 516
Published: Dec 26, 2019
Abstract
Tocosol™ is a tocopherol-based paclitaxel (PTX) nanoemulsion consisting of α-tocopherol (α-T) isomer of vitamin E as a solubilizer and vitamin E TPGS as the primary emulsifier. Despite its positive attributes in early clinical studies, it failed the pivotal phase III clinical trials. The long-term goal of this work was to reformulate Tocosol™. In this study, Tocosol™ formulation was optimized by replacing the α-T isomer with the more...
Paper Details
Title
Development and evaluation of paclitaxel nanoemulsion for cancer therapy
Published Date
Dec 26, 2019
Volume
25
Issue
4
Pages
510 - 516
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