Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue
Abstract
Despite recent evidence that 5-hydroxymethylcytosine (5hmC) possesses roles in gene regulation distinct from 5-methylcytosine (5mC), relatively little is known regarding the functions of 5hmC in mammalian tissues. To address this issue, we utilized an approach combining both paired bisulfite (BS) and oxidative bisulfite (oxBS) DNA treatment, to resolve genome-wide patterns of 5hmC and 5mC in normal breast tissue from disease-free women. Although...
Paper Details
Title
Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue
Published Date
Dec 16, 2019
Journal
Volume
15
Issue
4
Pages
398 - 418
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